ITGB1 anticorps (PE)

N° du produit ABIN238444

Cet anticorps Souris Monoclonal détecte spécifiquement ITGB1 dans FACS. Il présente une réactivité envers Humain, Porc et Chien.

Aperçu rapide pour ITGB1 anticorps (PE) (ABIN238444)

Antigène: ITGB1 (Integrin beta 1 (ITGB1))

Reactivité: Humain, Porc, Chien

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ITGB1 est conjugé à/à la PE

Application: Flow Cytometry (FACS)

Clone: MEM-101A

Détail du produit anti-ITGB1 anticorps (PE)

Purification: Size-Exclusion Chromatography

Immunogène: Raji Burkitt's lymphoma cell line

Isotype: IgG1

Information d'application

Indications d'application: Suitable for Flow Cytometry analysis of human blood cells using 20 m l reagent / 100 m l of whole blood or 10^6 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 15 mM Sodium Azide as preservative and 0.2 % (w/v) high-grade BSA (Protease free) as stabilizer

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody in the dark at 2-8 °C. Do Not Freeze! Avoid prolonged exposure to light.
Shelf Life: one year from despatch.

Date de péremption: 12 months

Détails sur ITGB1

Antigène: ITGB1 (Integrin beta 1 (ITGB1))

Autre désignation: CD29 / Integrin beta-1

Sujet: CD29 (beta1 integrin subunit, GPIIa) forms non-covalently linked heterodimers with at least 6 dibberent alpha chains (alpha1-alpha6, CD49a-f) determining the binding properties of beta1 (VLA) integrins. These integrins mediate cell adhesion to collagen, fibronectin, laminin and other extracellular matrix (ECM) components. This interaction hinders cell death, whereas disruption of anchorage to ECM leads to apoptosis. Decreased expression of most beta1 integrins correlates with acquiring multidrug resistance of tumour cells during selection in presence of antitumour drug. In platelets, translocation of intracellular pool of beta1 integrins to the plasma membrane following thrombin stimulation. These integrins are also up-regulated in leukocytes during emigration and extravascular migration and appear to be critically involved in regulating the immune cell trafficking from blood to tissue, as well as in regulating tissue damage and disease symptoms related to inflammatory bowel disease. Through a beta1 integrin-dependent mechanism, fibronectin and type I collagen enhance cytokine secretion of human airway smooth muscle in response to IL-1beta.Synonyms: FNRB, Fibronectin receptor subunit beta, ITGB1, Integrin VLA-4 subunit beta, MDF2, MSK12

UniProt: P05556

Pathways: Cell-Cell Junction Organization, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor, Integrin Complex, SARS-CoV-2 Protein Interactome